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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Withaferin A, Oxaliplatin
Phytochemical Name Withaferin A (PubChem CID: 265237 )
Anticancer drug Name Oxaliplatin (PubChem CID: 9887053 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Oxaliplatin
Adverse Reactions Nausea, vomiting, diarrhoea, loss of appetite. This was inferred cold nature anticancer drug.
Recommendations Hot: Datura metel; Citrus reticulata
Reference Traditional Chinese medicine characteristics of chemotherapy regimens in advanced gastrointestinal malignant tumours[J]. Global Traditional Chinese Medicine,2023,16(8):1596-1599. DOI:10.3969/j.issn.1674-1749.2023.08.019.　　ref_link
Combination Pair ID: 356
Ref_1
Pair Name Withaferin A, Oxaliplatin
Disease Info [ICD-11: 2C10] Pancreatic cancer Investigative
Biological Phenomena Induction-->ROS accumulation
Gene Regulation Down-regulation Phosphorylation AKT1 hsa207
Down-regulation Expression BCL2 hsa596
Down-regulation Phosphorylation BRAF hsa673
Down-regulation Activity CASP3 hsa836
Up-regulation Phosphorylation MAPK14 hsa1432
Up-regulation Phosphorylation MAPK8 hsa5599
Down-regulation Phosphorylation PDPK1 hsa5170
Down-regulation Phosphorylation PIK3R1 hsa5295
Down-regulation Expression XIAP hsa331
In Vitro Model PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens (Human) CVCL_0480
MIA PaCa-2 Pancreatic ductal adenocarcinoma Homo sapiens (Human) CVCL_0428
SW1990 Pancreatic adenocarcinoma Homo sapiens (Human) CVCL_1723
Result These results support the notion that combination treatment with oxaliplatin and WA could facilitate development of an effective strategy for PC treatment.
03. Reference
No. Title Href
1 Synergistic antitumor activity of withaferin A combined with oxaliplatin triggers reactive oxygen species-mediated inactivation of the PI3K/AKT pathway in human pancreatic cancer cells. Cancer Lett. 2015 Feb 1;357(1):219-230. doi: 10.1016/j.canlet.2014.11.026. Click
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